GENERATION OF FREE OXYGEN RADICALS BY LEU KOCYTES OF CHILDREN WITH THROMBOCYTOPENIC PURPURA - REGULATORY ROLE OF THE PRODUCTS OF PLATELET DEGRANULATION

We studied the free radical status in children with thrombocytopenic p urpura. The formation of reactive oxygen species was evaluated using l uminol-dependent chemiluminescence. The studied group consisted of 25 children divided in subgroups by the form of the disease and glucocort icoid treatment. We revealed that almost in all cases of the crisis sp ontaneous and activated chemiluminescence got intensified, though fell to normal values in clinical remission. The diversity of values can b e explained by specific features of pathogenesis in different forms of the disease, neutrophil-platelet interactions, the influence of gluco corticoids.