EFFECT OF TEMPERATURE ON THE THERMODYNAMIC PROPERTIES, KINETIC PERFORMANCE, AND STABILITY OF POLYBUTADIENE-COATED ZIRCONIA

This article describes the results of a study of the effect of tempera ture on the performance of a reversed-phase material prepared by coati ng polybutadiene (PBD) on porous zirconia. We examined the effect of t emperature on retention, efficiency, and stability of this phase. The thermodynamic properties were evaluated via the separation of alkylben zenes and a set of tricyclic antidepressant drugs at different tempera tures, while the intrinsic kinetic performance of the PBD phase at ele vated temperatures was examined by using alkylbenzenes as probe solute s, Moreover, the thermal stability was determined by measuring the dri ft in k' while continuously pumping a mobile phase at 100 degrees C. W e found that enthalpy changes were between -2 and -4 kcal/mol and that changes in selectivity varied with the type of solute, High temperatu res improved the column efficiency by 30%, mainly by accelerating the solute diffusion rate in the stationary phase. Finally, the PHD-coated zirconia phase was very stable at a temperature of 100 degrees C for at least 7000 column volumes.