Sm. Bonsib et C. Bromley, IMMUNOCYTOCHEMICAL ANALYSIS OF BAND-3 PROTEIN IN RENAL-CELL CARCINOMA, NEPHROBLASTOMA, AND ONCOCYTOMA, Archives of pathology and laboratory medicine, 118(7), 1994, pp. 702-704
Citations number
31
Categorie Soggetti
Pathology,"Medical Laboratory Technology","Medicine, Research & Experimental
Band 3 protein is an anion-exchange protein that in the human kidney i
s restricted to a subpopulation of collecting duct-intercalated cells;
however, it is absent in the metanephric-derived cells of the nephron
. We have studied band 3 protein expression in a series of 60 renal tu
mors that included 10 oncocytomas, 42 renal cell carcinomas, and eight
nephroblastomas by using frozen tumors and a monoclonal antibody. We
detected band 3 protein expression in nine of 10 oncocytomas but not i
n any renal cell carcinomas or nephroblastomas. This finding confirms
that band 3 protein is a specific marker for oncocytoma and therefore
may have a potential diagnostic application. It also supports the cont
ention that renal cell carcinoma and oncocytoma are histogenically unr
elated; the former is metanephric blastema derived and the latter is a
mpullary bud derived.