CD8-CELL LEUKEMIA( POLYLOBATED T)LYMPHOMA - A CASE-REPORT WITH IMMUNOPHENOTYPIC, ULTRASTRUCTURAL, GENE REARRANGEMENT, KARYOTYPIC, AND DNA CONTENT-ANALYSIS AND AUTOPSY DESCRIPTION/

Polylobated lymphoma is a morphologic variant of malignant lymphoma ch aracterized by large pleomorphic neoplastic cells with polylobated nuc lei. We report an unusual case in a 57-year-old man with a 9-year hist ory of an antecedent low-grade peripheral T-cell lymphoma with dermal involvement. The polylobated lymphoma expressed the CD2, 8, 45, and DR surface antigens and had a clonally rearranged T-cell receptor beta-c hain gene. The DNA content analysis indicated that most of the neoplas m was DNA diploid and tetraploid, with a high S phase. Cytogenetic ana lysis demonstrated the presence of a clone with an abnormal karyotype 45, X, -Y, -1, -10, -10, -17, -19, +5 mar. Serology and polymerase cha in reaction analysis showed no evidence of retroviral infection (human immunodeficiency virus types 1 and 2 and human T-cell lymphotropic vi rus types I and II). We review the literature on polylobated T-cell ly mphoma.