SOLUBILITY ENHANCEMENT OF TRIFLUMIZOLE BY HOST-GUEST INTERACTION WITHBETA-CYCLODEXTRIN

Authors
VIERNSTEIN H REITER S WOLSCHANN P
Citation
H. Viernstein et al., SOLUBILITY ENHANCEMENT OF TRIFLUMIZOLE BY HOST-GUEST INTERACTION WITHBETA-CYCLODEXTRIN, Monatshefte fuer Chemie, 125(6-7), 1994, pp. 681-689
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Monatshefte fuer Chemie → ACNP
ISSN journal
00269247
Volume
125
Issue
6-7
Year of publication
1994
Pages
681 - 689
Database
ISI
SICI code
0026-9247(1994)125:6-7<681:SEOTBH>2.0.ZU;2-9
Abstract
The solubility enhancement of triflumizole, a systemic fungicide, by b eta-cyclodextrin inclusion complexation was investigated by electron a bsorption spectroscopy. The respective association constant determined by different methods was estimated to 470 +/- 20 M-1 in aqueous solut ion. A model for the host-guest complexation was deduced by molecular calculations.