PREPARATION AND FUNGITOXICITY OF 3,6-DICHLORO-8-QUINOLINOLS AND 3,6-DIBROMO-8-QUINOLINOLS

3,6-Dichloro- and 3,6-dibromo-8-quinolinols were prepared by direct ha logenation of 8-nitroquinoline by N-halosuccinimide in acetic acid or by halogenation of the corresponding 6-halo-8-nitroquinoline prepared via a Skraup reaction. The nitro group was reduced to amino and the am ine was hydrolyzed to the phenol in 70% sulfuric acid at 220-degrees-C . The fungitoxicity of 3,6-dichloro- and 3,6-dibromo-8-quinolinols, as well as intermediates in their preparation, against Aspergillus niger , Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride, and Mucor cirinelloides was determined. 3,6-dichloro-8-quinolinol is the m ost fungitoxic analogue of this class of compounds observed to date.