Two cases of high-output heart failure associated with pulmonary hyper
tension are presented. In a 32-year-old man with hyperthyroidism, pulm
onary hypertension subsided after antithyroid therapy. Increased pulmo
nary blood flow and elevated left ventricular end-diastolic pressure w
ere suspected as the causes of pulmonary hypertension. In a 51-year-ol
d man with cardiac beriberi, the pulmonary hypertension improved after
thiamine administration. We suspect that increased pulmonary blood fl
ow, elevated left ventricular end-diastolic pressure, and probably pul
monary vasoconstriction were the causes of pulmonary hypertension. Thu
s, high-output heart failure should be considered as a possible cause
of pulmonary hypertension and right ventricular failure.