FACTORS AFFECTING THE BIOAVAILABILITY OF ANTHELMINTIC DRUGS IN RUMINANTS

The close relationship between pharmacokinetic behaviour and the clini cal efficacy of anthelmintic compounds is now well confirmed. The unde rstanding of potential factors affecting the plasma bioavailability of anthelmintic drug in animal production is crucial in optimizing their use and in reducing investment in parasite control. This article desc ribes a number of host and drug related factors that may affect pharma cokinetic behaviour and the resultant clinical efficacy of anthelminti c drug under field conditions.