DIABETES-MELLITUS IN CHILDHOOD CYSTIC-FIBROSIS

Since 1984, five patients in the cystic fibrosis (CF) clinic at Cork R egional Hospital have developed diabetes mellitus (DM) and were treate d with Insulin. None had received systemic corticosteroids but two had high calorie naso-gastric feeding regimes. Two died from lung disease . A fifteen year old boy developed bilateral cataracts. In nine other paediatric CF clinics in the Republic of Ireland (total: 420 patients) , three patients have DM, two receiving Insulin. Abnormal glucose tole rance is becoming more common in CF as patients survive longer. The po ssible role of corticosteroid treatment and intensive carbohydrate fee ding regimes in development of glucose intolerance must be considered. DM in CF differs from the usual childhood DM. Regular screening and e arly Insulin supplementation may be beneficial.