THE PHARMACOKINETICS OF FLUCONAZOLE AFTER A SINGLE INTRAVENOUS DOSE IN AIDS PATIENTS

The pharmacokinetics of fluconazole after a single 100 mg i.v. dose we re studied in 10 healthy subjects (5 M; 5 F) and 10 HIV-positive patie nts (8 M; 2 F). The mean value of plasma clearance was 25% lower in th e patient groups (17 +/- 6 (s.d.) vs 23 +/- 4 ml min(-1); 95% CI of di fference -11 to -0.7; P < 0.05). This difference may have been related to slightly reduced kidney function in the patient group (mean creati nine clearance -18%) but is unlikely to be clinically significant. The refore, no adjustment of the dose of intravenously administered flucon azole appears to be necessary in AIDS patients without clinical signs of enteropathy.