SEPARATION OF OVERLAPPING SPECTRA FROM EVOLVING SYSTEMS USING FACTOR-ANALYSIS .2. AMPHOTERICIN-B IN AQUEOUS PROPANOL AND IN AQUEOUS LAUROYLSUCROSE

Authors
CHAPADOS C BARWICZ J GRUDA I
Citation
C. Chapados et al., SEPARATION OF OVERLAPPING SPECTRA FROM EVOLVING SYSTEMS USING FACTOR-ANALYSIS .2. AMPHOTERICIN-B IN AQUEOUS PROPANOL AND IN AQUEOUS LAUROYLSUCROSE, Biophysical chemistry, 51(1), 1994, pp. 71-80
Citations number
17
Categorie Soggetti
Biophysics,Biology,"Chemistry Physical
Journal title
Biophysical chemistry → ACNP
ISSN journal
03014622
Volume
51
Issue
1
Year of publication
1994
Pages
71 - 80
Database
ISI
SICI code
0301-4622(1994)51:1<71:SOOSFE>2.0.ZU;2-L
Abstract
A method based on factor analysis is used to separate the spectra of i ndividual species from the experimental absorption spectra obtained fr om a fixed amount of amphotericin B dissolved in aqueous solutions. In aqueous propanol solutions and in aqueous lauroyl sucrose solutions, five species are identified: two monomers and three aggregates. Althou gh the spectra of the different species in the two media are similar, the intensity signatures of the two systems are quite different and se rve to characterize them.