CLINICAL AND BIOLOGICAL SIGNIFICANCE OF C HROMOSOMAL DEFECTS IN CHILDHOOD ACUTE LEUKEMIAS

Chromosomal examination was made in the bone marrow and lymphocytes of the peripheral blood of 37 children with acute leukemia. Of them 25 h ad acute lymphoblastic leukemia (ALL), 12 had acute nonlymphoblastic l eukemia (ANLL). NA karyotype was registered in 13 patients (5 with ALL , 9 with ANLL), AA karyotype in 17 children (12 with ALL, 5 with ANLL) . In All the following chromosomal markers were identified: del (6)/(q 22), del(7)(q32), del(11)(q23), 9p+, t(8; 14) (q24; q32). In ANLL ther e were: 46, XY, f(3; 8)/46, XY; 47, XY, +16, +(2; 14)-M1-form; 46, XX, t(8; 21); 46, XX, t(8; 21)/46, XX-M2-form; 47, XX, +mar/46, XX; 47, X Y, +12-M4-form; 46, XX, del(16)/46, XX, 47, XY, +16; 48, XY, +5, +8-M5 -form FAB.