THE RESULTS OF INTENSIVE THERAPY IN ACUTE -LEUKEMIA CHILDREN

The authors report the results of the treatment according to the progr ams BFM-ALL-90 and BFM-AML-83 and 87. A total of 110 children with acu te lymphoblastic leukemia (ALL) and 35 with acute myeloblastic leukemi a (AML) were treated with remission rate 94,5 % and 74.5 %, respective ly. Under programmed treatment of ALL the recurrences occurred in 12.2 % against 46 % of the cases in nonprogrammed treatment. 2-year surviv al made up 75 % and 47.3 %, respectively. Among AML cases there were f requently prognostically unfavorable ones and patients with neuroleuke mia this dictating the necessity of the treatment intensification and irradiation of the skull in AML. Improvement of adjuvant therapy is a must in advance of acute leukemia treatment.