FETUSES WITH CHOROID-PLEXUS CYSTS ARE AT HIGH-RISK FOR DOWN-SYNDROME

Objective: To determine the risk of Down syndrome in the second-trimes ter fetuses with choroid plexus cyst(s) in Taiwanese. Methods: A prosp ective study was performed during a period of 35 months to collect fet uses with choroid plexus cyst(s) diagnosed by routine ultrasound scree ning at the second trimester. Amniocentesis and detailed ultrasound we re then performed. Results: Totally 108 fetuses with choroid plexus cy st(s) were available. Ten fetuses had chromosomal aberrations, includi ng two trisomy 21, one mosaic trisomy 21, and seven trisomy 18. The ri sks of trisomy 18 and Down syndrome in second-trimester fetuses with c horoid plexus cyst(s) were 1:15.4 (7/108) and 1:36 (3/108), respective ly. Conclusions: These data implicated that fetuses with choroid plexu s cyst(s) are at high risk for aneuploidy, not only trisomy 18 but als o Down syndrome.