PREVENTION OF RENAL TUBULE REABSORPTION OF RADIOMETAL (IN-111) LABELED FAB FRAGMENT OF A MONOCLONAL-ANTIBODY IN MICE BY SYSTEMIC ADMINISTRATION OF LYSINE

Authors
PIMM MV GRIBBEN SJ
Citation
Mv. Pimm et Sj. Gribben, PREVENTION OF RENAL TUBULE REABSORPTION OF RADIOMETAL (IN-111) LABELED FAB FRAGMENT OF A MONOCLONAL-ANTIBODY IN MICE BY SYSTEMIC ADMINISTRATION OF LYSINE, European journal of nuclear medicine, 21(7), 1994, pp. 663-665
Citations number
7
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
European journal of nuclear medicine → ACNP
ISSN journal
03406997
Volume
21
Issue
7
Year of publication
1994
Pages
663 - 665
Database
ISI
SICI code
0340-6997(1994)21:7<663:PORTRO>2.0.ZU;2-Z
Abstract
Systemic administration of lysine to mice injected with indium-111-lab elled Fab fragment of a monoclonal antibody has been shown to reduce r enal uptake/retention of the radiometal. This treatment should be appl icable to clinical immunoscintigraphy and radioimmunotherapy with radi ometal-labelled antibody fragments.