PROTEIN-C IS RESPONSIBLE FOR THE RAPID INACTIVATION OF FACTOR VA FOLLOWING BLOOD-CLOTTING IN-VITRO

Authors
JACKSON DE MITCHELL CA SALEM HH
Citation
De. Jackson et al., PROTEIN-C IS RESPONSIBLE FOR THE RAPID INACTIVATION OF FACTOR VA FOLLOWING BLOOD-CLOTTING IN-VITRO, Thrombosis and haemostasis, 72(1), 1994, pp. 70-73
Citations number
16
Categorie Soggetti
Hematology,"Cardiac & Cardiovascular System
Journal title
Thrombosis and haemostasis → ACNP
ISSN journal
03406245
Volume
72
Issue
1
Year of publication
1994
Pages
70 - 73
Database
ISI
SICI code
0340-6245(1994)72:1<70:PIRFTR>2.0.ZU;2-9
Abstract
When whole blood is allowed to clot in vitro, factor V is rapidly acti vated to factor Va which is subsequently inactivated. We developed two monoclonal anti-protein C antibodies, one of which inhibits protein C activation and the other inhibits protein C activity. The addition of either antibody to blood before clotting in vitro significantly inhib ited the inactivation of factor Va, confirming the essential role of p rotein C in mediating the rapid inactivation of factor Va.