De. Swayne et Dj. Alexander, CONFIRMATION OF NEPHROTROPISM AND NEPHROPATHOGENICITY OF 3 LOW-PATHOGENIC CHICKEN-ORIGIN INFLUENZA-VIRUSES FOR CHICKENS, Avian pathology, 23(2), 1994, pp. 345-352
Specific pathogen-free chickens were inoculated intravenously with one
of three low-pathogenic chicken-origin influenza virus isolates. On d
ay 5 post-inoculation, most chickens had gross and histological kidney
lesions. Influenza virus of high titre was recovered from the kidneys
and influenza nucleoprotein, detected immunohistochemically was local
ized in necrotic renal tubule epithelium. These data indicate low-path
ogenic influenza viruses can be nephrotropic and nephropathogenic, and
corroborate gross observations from some low-pathogenic influenza out
breaks in laying hens.