THE ROLE OF PLATELET-ACTIVATING-FACTOR (PAF) IN INTERSTITIAL PULMONARY-DISEASE

Platelet-activating factor (PAF) is a biolipid of crucial importance i n the inflammatory response. In the first part of this work we review the basic biochemical characteristics of PAF Also, the production and degradation of PAF by inflammatory cells is detailed in depth, with a description of enzymes linked to these processes. Subsequently, we exa mine the main characteristics of the generation of PAF by pulmonary ce lls, with emphasis on its production by alveolar macrophages. We then discuss in depth the effects of this biolipid on the inflammatory cell s present in interstitial disease. In this part of the review we descr ibe the direct effect of PAF on polymorphonuclear leukocytes (neutroph ils and eosinophils), mononuclear phagocyte system cells, lymphocytes and endothelial cells. We then examine the indirect effect of PAF on i nflammatory cells (mainly due to an interaction with neuropeptides). F inally, we discuss the data on the role of PAF in diffuse interstitial pulmonary disease (both human and experimental).