INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY

Red blood cell lysis photosensitized by Ketoprofen, 2-(3-benzoxyphenyl )propionic acid (KPF), was investigated in the presence of some copper (II) complexes with linear and cyclic dipeptides as well as functional ized beta-cyclodextrins with SOD-like activity with the aim of ascerta ining their protective activity towards the photoinduced cell damage. The comparison between the decrease of photolytic activity caused by t hese complexes and their superoxide dismutase activity showed an appre ciable correlation. The correct determination of species existing in e xperimental conditions was obtained through a simulation approach base d on the knowledge of the stability constants of the complexes.