Ga. Lambert, SOFTWARE-CONTROLLED TESTING FOR ANTIDROMIC ACTIVATION OF SINGLE NEURONS, Computer applications in the biosciences, 10(3), 1994, pp. 237-241
This paper describes a technique which allows the determination of the
shape of action potentials initiated spontaneously, orthodromically o
r antidromically, without the distorting effects on shape that may be
produced by changes in latency of activation or by signal averaging te
chniques. Software-controlled stimulation allows precise control of pa
rameters for antidromic collision testing. The method allows selective
sampling of a single action potential from a rapidly discharging cell
,from a population of similar cells or from a evoked action potential
among spontaneous activity. It minimizes jitter in the antidromic peri
-event histogram by presenting an antidromic stimulus at precise and r
eproducible delays following either a spontaneous or orthodromically e
voked action potential.