GLYCOHEMOGLOBIN MEASURED BY AUTOMATED AFFINITY HPLC CORRELATES WITH BOTH SHORT-TERM AND LONG-TERM ANTECEDENT GLYCEMIA

Citation
Wt. Cefalu et al., GLYCOHEMOGLOBIN MEASURED BY AUTOMATED AFFINITY HPLC CORRELATES WITH BOTH SHORT-TERM AND LONG-TERM ANTECEDENT GLYCEMIA, Clinical chemistry, 40(7), 1994, pp. 1317-1321
Citations number
29
Categorie Soggetti
Chemistry Medicinal
Journal title
ISSN journal
00099147
Volume
40
Issue
7
Year of publication
1994
Pages
1317 - 1321
Database
ISI
SICI code
0009-9147(1994)40:7<1317:GMBAAH>2.0.ZU;2-8
Abstract
We evaluated glycohemoglobin (GHb) and glycated plasma protein (GPP) b y automated affinity HPLC for their ability to monitor both short-term and long-term antecedent glycemia in 70 diabetic subjects. We placed 30 subjects on an intervention protocol in which insulin and (or) diet ary changes were made twice weekly to acutely decrease glycemia. We mo nitored 40 subjects at 6-week intervals; changes in the clinical regim en were made at that time only. Despite weekly changes in mean blood g lucose in the subjects who received more intensive intervention, GHb c oncentrations correlated significantly with the weekly (r = 0.66, P <0 .001), 2-week (r = 0.70, P <0.001), 3-week (r = 0.72, P <0.001), and 6 -week (r = 0.83, P <0.001) mean glucose concentrations. GPP correlated significantly with measured glycated albumin determined by boronate a ffinity columns (r = 0.83, P <.001) and correlated best with the 1-wee k (r = 0.66, P <0.001), 2-week (r = 0.64, P <.001) and 3-week (r = 0.6 0, P <0.001) mean antecedent glucose concentration. Thus, GHb, traditi onally considered a marker for only long-term diabetic control, correl ated significantly with both shortterm and long-term antecedent glycem ia.