Methadone maintenance has been used for decades to treat opioid-depend
ent pregnant women. The outcomes of pregnancies thus treated are vastl
y improved over the outcomes of pregnancies complicated by street drug
use. Despite its long history of successful use during pregnancy, lit
tle is known about the long-term effects of methadone on the fetus and
the newborn. Studies done in animals suggest there may be subtle effe
cts on brain and behavior. Only recently have other treatments for opi
oid dependency during pregnancy been investigated. There is increasing
evidence that altering the traditional methadone maintenance protocol
s may be beneficial, and that tapered withdrawal can be safely achieve
d under some circumstances.