PROCTOLIN AND ITS ANALOGS - STRUCTURE BIOLOGICAL FUNCTION RELATIONSHIP STUDIES

Authors
KONOPINSKA D ROSINSKI G SOBOTKA W PLECH A
Citation
D. Konopinska et al., PROCTOLIN AND ITS ANALOGS - STRUCTURE BIOLOGICAL FUNCTION RELATIONSHIP STUDIES, Polish Journal of Chemistry, 68(7), 1994, pp. 1437-1439
Citations number
4
Categorie Soggetti
Chemistry
Journal title
Polish Journal of Chemistry → ACNP
ISSN journal
01375083
Volume
68
Issue
7
Year of publication
1994
Pages
1437 - 1439
Database
ISI
SICI code
0137-5083(1994)68:7<1437:PAIA-S>2.0.ZU;2-H
Abstract
The object of our studies was the synthesis of the insect neuropeptide proctolin (Arg-Tyr-Leu-Pro-Thr) and its 42 analogues modified in posi tions 1-4. The activities of proctolin and its analogues were examined in various biological preparations, such as: myotropic effects in sel ected insect species in vitro and behaviour of rats in vivo. The struc ture/activity relationship in these varied preparations will be discus sed.