MYOCARDIAL KINETICS OF K-38 IN HUMANS AND COMPARISON WITH COPPER-62-PTSM

Citation
Pg. Melon et al., MYOCARDIAL KINETICS OF K-38 IN HUMANS AND COMPARISON WITH COPPER-62-PTSM, The Journal of nuclear medicine, 35(7), 1994, pp. 1116-1122
Citations number
29
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
ISSN journal
01615505
Volume
35
Issue
7
Year of publication
1994
Pages
1116 - 1122
Database
ISI
SICI code
0161-5505(1994)35:7<1116:MKOKIH>2.0.ZU;2-B
Abstract
The aim of this study was to define the kinetics of K-38 and its suita bility to evaluate myocardial blood flow at rest and during pharmacolo gical vasodilation in normal subjects. Potassium-38's kinetic characte ristics were also compared to those of a Cu-62-pyruvaldehyde bis((n)4- methyl-thio-semicarbazone) copper (II) (PTSM) flow tracer. Methods: Po tassium-38 and (CU)-C-62-PTSM were injected at rest and after pharmaco logical vasodilation in six healthy volunteers. Dynamic PET acquisitio n was performed over 20 min and myocardial tracer retention calculated . Homogeneity of regional myocardial tracer distribution was also eval uated. Results: High image quality of the heart was observed at rest a nd after dipyridamole with both tracers. Potassium-38 demonstrated pro longed myocardial retention with minimal lung and liver accumulation. In contrast to K-38, Cu-62-PTSM demonstrated high liver uptake which m ay hinder observation of the inferior wall of the myocardium. Copper-6 2-PTSM dipyridamole-to-rest retention ratio was 1.49. Conclusions: Pot assium-38 and Cu-62-PTSM display suitable kinetics for the qualitative evaluation of blood flow and flow reserve in the human heart. Compare d to Cu-62-PTSM, potassium-38, which does not show high liver uptake, may more accurately estimate blood flow in the inferior wall of the he art. However, accurate quantification of myocardial blood flow using K -38 or Cu-62-PTSM retention appears to be limited to decreasing retent ion fraction at hyperhemic states.