Background: Lack of complete jaw relaxation after a halothane-succinyl
choline sequence has been described in the literature. To date, howeve
r, most existing studies are retrospective, and lack agreement on the
magnitude and incidence of this phenomenon. This prospective study exa
mined the incidence and degree of incomplete jaw relaxation in 500 chi
ldren who were given intravenous succinylcholine during halothane anes
thesia. Methods: Five hundred consecutive unmedicated children receive
d a minimum dose of 2 mg/kg intravenous succinylcholine after inductio
n of anesthesia with halothane. The degree of jaw relaxation was asses
sed 45-60 s later by the same observer using a standardized clinical s
cale. The degree of relaxation was correlated with the type of surgica
l procedure, and the presence and intensity of fasciculations. Results
: Complete relaxation (mouth opened easily and fully) occurred in 95.4
% of study patients. Incomplete relaxation (firm manual separation req
uired to open the mouth fully) was seen in 4.4% of the patients. One c
hild (0.2%) had masseter muscle rigidity (mouth could not be fully ope
ned but intubation possible). There were no incidents of trismus (teet
h clamped shut and intubation via direct visualization impossible). Th
e incidence of incomplete relaxation and masseter muscle rigidity did
not correlate with the presence or degree of fasciculations or the typ
e of surgical procedure. There were no clinical signs of a hypermetabo
lic state or myoglobinuria in any patient. Conclusions: Incomplete jaw
relaxation after a halothane-succinylcholine sequence is not uncommon
in children, and is considered a normal response.