PHYSICAL ASSOCIATION OF JAK1 AND JAK2 TYROSINE KINASES WITH THE INTERLEUKIN-2 RECEPTOR-BETA AND GAMMA-CHAINS

Authors
TANAKA N ASAO H OHBO K ISHII N TAKESHITA T NAKAMURA M SASAKI H SUGAMURA K
Citation
N. Tanaka et al., PHYSICAL ASSOCIATION OF JAK1 AND JAK2 TYROSINE KINASES WITH THE INTERLEUKIN-2 RECEPTOR-BETA AND GAMMA-CHAINS, Proceedings of the National Academy of Sciences of the United Statesof America, 91(15), 1994, pp. 7271-7275
Citations number
37
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
91
Issue
15
Year of publication
1994
Pages
7271 - 7275
Database
ISI
SICI code
0027-8424(1994)91:15<7271:PAOJAJ>2.0.ZU;2-V
Abstract
The functional interleukin 2 (IL-2) receptors contain the beta and gam ma chains which are necessary for the transduction of cell growth sign als. Monoclonal antibodies specific for the beta chain and gamma chain coimmunoprecipitated JAK1 and 114-kDa JAK2 tyrosine kinases, respecti vely. Tyrosine phosphorylation of JAK1 and JAK2, was induced upon IL-2 stimulation, and IL-2 activated the JAK2 kinase. These results demons trate that the JAK1 and JAK2 tyrosine kinases are physically associate d with the beta chain and gamma chain, respectively, and suggest that regulation of the kinases may be linked to IL-2-induced signal transdu ction.