TRITIUM AMS FOR BIOMEDICAL APPLICATIONS

We are developing H-3 AMS to measure H-3 activity of mg-sized biologic al samples. LLNL has already successfully applied C-14 AMS to a variet y of problems in the area of biomedical research. Development of H-3 A MS would greatly complement these studies. The ability to perform H-3 AMS measurements at sensitivities equivalent to those obtained for C-1 4 will allow us to perform experiments using compounds that are not re adily available in C-14-tagged form. A H-3 capability would also allow us to perform unique double-labeling experiments in which we learn th e fate, distribution, and metabolism of separate fractions of biologic al compounds.