EFFECT OF GLASS BIOACTIVITY ON NEW BONE-DEVELOPMENT INDUCED BY DEMINERALIZED BONE-MATRIX IN A RAT EXTRASKELETAL SITE

The effects of two kinds of bioactive glass and two kinds of phosphate -free glass on new bone development induced by demineralized bone matr ix (DBM) were studied in the rat abdominal muscle pouch model. After 8 weeks' implantation histomorphometric analysis revealed that the amou nt of new bone in DBM combined with bioactive glass was comparable to DBM without bioactive glass. DBM grafts combined with phosphate-free g lass showed significantly less new bone formation. Scanning electron m icroscopic examination confirmed that new bone bonded to the surface o f bioactive glass. The release of ions from the glass seemed to slow d own after new bone had bonded to it. Exclusion of phosphate from a bio active glass resulted in loss of ability to develop the Ca,P-rich surf ace layer needed for bone bonding.