ANTI-GMP140 (CD62) AUTOANTIBODY IN A PATIENT WITH AUTOIMMUNE THROMBOCYTOPENIC PURPURA

Authors
BIERLING P BETTAIEB A FROMONT P FAVRIN M DUEDARI N
Citation
P. Bierling et al., ANTI-GMP140 (CD62) AUTOANTIBODY IN A PATIENT WITH AUTOIMMUNE THROMBOCYTOPENIC PURPURA, British Journal of Haematology, 87(3), 1994, pp. 631-633
Citations number
11
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
87
Issue
3
Year of publication
1994
Pages
631 - 633
Database
ISI
SICI code
0007-1048(1994)87:3<631:A(AIAP>2.0.ZU;2-P
Abstract
The presence of platelet GMP140 (CD62) antibodies was analysed by the MAIPA test in 57 sera from patients with AITP and on platelets from 54 patients with thrombocytopenia of suspected immune origin. A CD62 ant ibody was found in only one serum. Its specificity was confirmed by an ELISA and a radioimmunoprecipitation procedure using total intact pla telets and immuno-purified GMP140. An increased amount of platelet-ass ociated (PA) IgG, due to in vivo fixation of GMP140 and GpIIb/IIIa ant ibodies, was also found on the patient platelet membrane, suggesting t hat GMP140 autoantibody may contribute to immune platelet destruction. No increase in PAGMP140 antibody was found on the other 54 platelet s uspensions.