SOMATOMEDIN-C (INSULIN-LIKE GROWTH-FACTOR-1) LEVELS DECREASE DURING ACUTE CHANGES OF STRESS-RELATED HORMONES - RELEVANCE FOR FIBROMYALGIA

Citation
G. Ferraccioli et al., SOMATOMEDIN-C (INSULIN-LIKE GROWTH-FACTOR-1) LEVELS DECREASE DURING ACUTE CHANGES OF STRESS-RELATED HORMONES - RELEVANCE FOR FIBROMYALGIA, Journal of rheumatology, 21(7), 1994, pp. 1332-1334
Citations number
14
Categorie Soggetti
Rheumatology
Journal title
ISSN journal
0315162X
Volume
21
Issue
7
Year of publication
1994
Pages
1332 - 1334
Database
ISI
SICI code
0315-162X(1994)21:7<1332:S(GLDD>2.0.ZU;2-N
Abstract
Objective. To determine the effects of stress hormones on insulin-like growth factor 1 (IGF-1). Methods. Insulin induced hypoglycemia (< 3 m mol/l) and clonidine induced depression of noradrenergic tone were use d to assess the acute effects of cortisol, human growth hormone (hGH), and norepinephrine (NE). Results. Despite the increase of hGH during hypoglycemia, a statistically significant decrease of IGF-1 was observ ed along with the expected rise of cortisol and NE. To eliminate the r ole played by NE, NE tone was depressed by administering clonidine. A statistically significant decrease of IGF-1 was also observed. Conclus ion. Acute cortisol release or a NE decrease induce low IGF-1 levels.