G. Ferraccioli et al., SOMATOMEDIN-C (INSULIN-LIKE GROWTH-FACTOR-1) LEVELS DECREASE DURING ACUTE CHANGES OF STRESS-RELATED HORMONES - RELEVANCE FOR FIBROMYALGIA, Journal of rheumatology, 21(7), 1994, pp. 1332-1334
Objective. To determine the effects of stress hormones on insulin-like
growth factor 1 (IGF-1). Methods. Insulin induced hypoglycemia (< 3 m
mol/l) and clonidine induced depression of noradrenergic tone were use
d to assess the acute effects of cortisol, human growth hormone (hGH),
and norepinephrine (NE). Results. Despite the increase of hGH during
hypoglycemia, a statistically significant decrease of IGF-1 was observ
ed along with the expected rise of cortisol and NE. To eliminate the r
ole played by NE, NE tone was depressed by administering clonidine. A
statistically significant decrease of IGF-1 was also observed. Conclus
ion. Acute cortisol release or a NE decrease induce low IGF-1 levels.