THE ACTION OF SYNTHETIC CANNABINOIDS ON THE INDUCTION OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE

Authors
COLLINS DR PERTWEE RG DAVIES SN
Citation
Dr. Collins et al., THE ACTION OF SYNTHETIC CANNABINOIDS ON THE INDUCTION OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE, European journal of pharmacology, 259(3), 1994, pp. 180000007-180000008
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
259
Issue
3
Year of publication
1994
Pages
180000007 - 180000008
Database
ISI
SICI code
0014-2999(1994)259:3<180000007:TAOSCO>2.0.ZU;2-A
Abstract
Incubation of rat hippocampal slices with the synthetic cannabinoid (- )-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation of field excitatory postsynaptic potentials recorded in the CA1 region. However, in slice s incubated with its non-psychoactive(+)-isomer HU-211 (100 nM), which is reported to be an NMDA receptor antagonist, high frequency stimula tion evoked a long-lasting potentiation, comparable to control slices.