PARALLEL SYNTHESIS AND ANALYSIS OF LARGE NUMBERS OF RELATED CHEMICAL-COMPOUNDS - APPLICATIONS TO OLIGONUCLEOTIDES

Authors
SOUTHERN EM MASKOS U
Citation
Em. Southern et U. Maskos, PARALLEL SYNTHESIS AND ANALYSIS OF LARGE NUMBERS OF RELATED CHEMICAL-COMPOUNDS - APPLICATIONS TO OLIGONUCLEOTIDES, Journal of biotechnology, 35(2-3), 1994, pp. 217-227
Citations number
48
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Journal of biotechnology → ACNP
ISSN journal
01681656
Volume
35
Issue
2-3
Year of publication
1994
Pages
217 - 227
Database
ISI
SICI code
0168-1656(1994)35:2-3<217:PSAAOL>2.0.ZU;2-M
Abstract
This review presents methods for addressing the issue of molecular com plexity in biological systems. Biomolecules immobilised on solid phase s can be used to probe biological interactions. As a specific example, arrays of large numbers of oligonucleotides allow the analysis of DNA sequences and complex populations of DNA molecules. The specific embo diments of this new method are presented, research up to mid-1992 outl ined and requirements for future development discussed.