ENHANCED IMMUNOGENICITY OF LEUCINE-ENKEPHALIN FOLLOWING COUPLING TO ANTIIMMUNOGLOBULIN AND ANTI-CD3 ANTIBODIES

Authors
HENDRICKSON TL WILSON GS FRAZER JM LIU RS MCCORMACK RT WOLFERT RL
Citation
Tl. Hendrickson et al., ENHANCED IMMUNOGENICITY OF LEUCINE-ENKEPHALIN FOLLOWING COUPLING TO ANTIIMMUNOGLOBULIN AND ANTI-CD3 ANTIBODIES, Journal of immunological methods, 172(2), 1994, pp. 165-172
Citations number
24
Categorie Soggetti
Immunology
Journal title
Journal of immunological methods → ACNP
ISSN journal
00221759
Volume
172
Issue
2
Year of publication
1994
Pages
165 - 172
Database
ISI
SICI code
0022-1759(1994)172:2<165:EIOLFC>2.0.ZU;2-2
Abstract
Leucine enkephalin (Leu-enk) was coupled to both T and B cell antibodi es in order to investigate the possibility of enhanced immunogenicity via targeted immunization. The two antibodies used were Hm x Mo CD3 an d Gt x Mo Ig, respectively. The data indicate that while both antibody carriers enhanced the immunogenicity of Leu-enk, the use of the Hm x Mo CD3 antibody resulted in a greater number of mice with positive Leu -enk specific serum titers. 12 Leu-enk cell lines were produced and on e, LE4H8, was chosen for characterization.