2-CHLORO-N(6)-CYCLOPENTYLADENOSINE (CCPA), AN ADENOSINE-A(1) RECEPTORAGONIST, SUPPRESSES ETHANOL WITHDRAWAL SYNDROME IN RATS

Authors
CONCAS A CUCCHEDDU T FLORIS S MASCIA MP BIGGIO G
Citation
A. Concas et al., 2-CHLORO-N(6)-CYCLOPENTYLADENOSINE (CCPA), AN ADENOSINE-A(1) RECEPTORAGONIST, SUPPRESSES ETHANOL WITHDRAWAL SYNDROME IN RATS, Alcohol and alcoholism, 29(3), 1994, pp. 261-264
Citations number
16
Categorie Soggetti
Substance Abuse
Journal title
Alcohol and alcoholism → ACNP
ISSN journal
07350414
Volume
29
Issue
3
Year of publication
1994
Pages
261 - 264
Database
ISI
SICI code
0735-0414(1994)29:3<261:2(AAR>2.0.ZU;2-F
Abstract
The ability of 2-chloro-N6-cyclopentyladenosine (CCPA) to suppress eth anol withdrawal syndrome was tested in male rats rendered physically d ependent on ethanol by intragastric administrations of ethanol (12-18 g/kg daily for 6 days). CCPA administered 24 hr after the last ethanol dose produced a dose-dependent inhibition of withdrawal signs such as tremors and audiogenically induced seizures, an effect prevented by t he A1 receptor antagonist 8-cyclopentyl-1,3-diproplyxanthine (DPCPX).