A NEW CHIRAL STATIONARY-PHASE - HEPTAKIS( I-O-N-BUTYL-3-O-TRIFLUOROACETYL)-BETA-CYCLODEXTRIN

A new chiral stationary phase, heptakis i-O-n-butyl-3-O-trifluoroacety l)-beta-cyclodextrin (DB-TFA-beta-CD), has been prepared from native b eta-cyclodextrin, and coated on fused silica capillary column. The sep arations of optical isomers including halohydrocarbon, epoxy compounds , ketones, alcohols, diols, amines, carboxylic acids, and amino acids have been achieved. The results showed that the acyl groups of alcohol derivatives played a significant role in their enantioselective separ ations. The choice of an acylation reagent can mean the difference bet ween success and failure in obtaining an enantiomeric sparation of alc ohol. Iso-leucine, allo-isoleucine, and proline which were seriously o verlapped or poorly separated by amide CSPs were base-lined resoved on this CSP.