TREATMENT OF RESISTANT PERITONITIS IN CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS WITH INTRAPERITONEAL UROKINASE - A DOUBLE-BLIND CLINICAL-TRIAL

Resistant peritonitis in continuous ambulatory peritoneal dialysis (CA PD) is an indication for catheter removal, followed by interim haemodi alysis and subsequent catheter replacement. This involves two surgical procedures using general anaesthetic and the availability of adequate hospital haemodialysis facilities. Urokinase is an alternative therap y but evidence of its effect is anecdotal and it has not been studied in a double-blind manner. Patients with resistant peritonitis (either no resolution of peritonitis within 4 days of appropriate antibiotic t herapy or a third episode of peritonitis within 6 months) were randomi zed to receive intraperitoneal urokinase or placebo (saline) followed by 14 days of antibiotics in this double-blind prospective study. Trea tment success was resolution of peritonitis within 4 days of giving ur okinase/placebo (persistent infection) and no recurrence with the same organism for 6 months (recurrent infection). Twelve patients received urokinase and 12 placebo. Treatment was successful in 8/12 in the uro kinase group and 1/12 in the placebo group (Fisher's exact test; P = 0 .0047). Urokinase was successful in 8/12 patients with resistant perit onitis and significantly better than placebo. Urokinase is an effectiv e and simple treatment that may avoid the need for catheter removal an d interim haemodialysis in patients with resistant CAPD peritonitis.