Jh. Check et al., EVALUATION OF WHETHER USING HCG TO STIMULATE OOCYTE RELEASE HELPS OR DECREASES PREGNANCY RATES FOLLOWING INTRAUTERINE INSEMINATION, Gynecologic and obstetric investigation, 38(1), 1994, pp. 57-59
The study's objective was to determine if using human chorionic gonado
tropin (hCG) as a timing method for intrauterine insemination (IUI) in
patients who make mature follicles but have cervical factor problems
has a negative effect on pregnancy rates (PRs) (possibly by releasing
an immature oocyte), or increases the rate of luteinized unruptured fo
llicles (LUF). Patients were offered hCG or natural release after an e
xplanation of the theoretical advantages and disadvantages. Intrauteri
ne insemination was performed 36-40 h after hCG; timing of IUI with hC
G was based on day of luteinizing hormone (LH) surge modified by serum
progesterone (P). Incidence of LUF in those taking hCG - 5/116 (4.3%)
; 0/33 without hCG. Pregnancies - 24/116 (20%) with hCG; 3/30 (10%) wi
thout hCG. No statistical differences in these rates were found. Thus,
using hCG for more convenient timing for IUI in nonsuperovulated cycl
es does not decrease the PR or cause a high incidence of LUF.