BIOCHEMICAL GENETICS OF METHYLGLYOXAL DEHYDROGENASES IN THE LABORATORY RAT (RATTUS-NORVEGICUS)

Authors
BENDER K SEIBERT RT WIENKER TF KREN V PRAVENEC M BISSBORT S
Citation
K. Bender et al., BIOCHEMICAL GENETICS OF METHYLGLYOXAL DEHYDROGENASES IN THE LABORATORY RAT (RATTUS-NORVEGICUS), Biochemical genetics, 32(5-6), 1994, pp. 147-154
Citations number
17
Categorie Soggetti
Genetics & Heredity",Biology
Journal title
Biochemical genetics → ACNP
ISSN journal
00062928
Volume
32
Issue
5-6
Year of publication
1994
Pages
147 - 154
Database
ISI
SICI code
0006-2928(1994)32:5-6<147:BGOMDI>2.0.ZU;2-A
Abstract
A genetic locus controlling the electrophoretic mobility of a methylgl yoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fired either allele Mgd1(a) or allele Mgd1(b). Codominant express ion is observed in heterozygotes, providing evidence for a tetramer c enzyme structure. Backcross progenies showed the expected 1:1 segregat ion ratio, and there is evidence that Mgd1 is linked to Pep3 and Fh1 o n chromosome 13. There is also evidence for two additional methylglyox al dehydrogenases: Mgd2, present in liver and kidney, and Mgd3, presen t only in heart.