ANTIBODY-RESPONSES OF HEALTHY INFANTS TO A RECOMBINANT HEPATITIS-B VACCINE ADMINISTERED AT 2-MONTHS, 4-MONTHS, AND 12-MONTHS OR 15-MONTHS OF AGE

Hepatitis B vaccine was administered to healthy infants on two investi gational schedules that fall within ranges recommended by the U.S. Pub lic Health Service Advisory Committee on Immunization Practices and by the American Academy of Pediatrics Committee on Infectious Diseases. A month after receiving vaccine at 2, 4, and 12 or 15 months of age, 9 8% and 100% of the children had >10 mIU antibodies to hepatitis B surf ace antigen per milliliter, with gemometric mean titers of 1358 mIU/ml and 3424 mIU/mL, respectively.