NEPHROCALCINOSIS AND NEPHROLITHIASIS IN INFANTS WITH CONGESTIVE-HEART-FAILURE TREATED WITH FUROSEMIDE

Nephrocalcinosis and nephrolithiasis developed in five children after furosemide therapy for congestive heart failure. In four children rena l calcifications were detected by ultrasonography and in one by autops y. Discontinuation of the loop diuretic in three children resulted in resolution of the calcifications in two of the patients. Residual rena l morbidity included reduced creatinine clearance, microscopic hematur ia, and hypercalciuria. The phenomenon of renal calcifications associa ted with furosemide treatment is more frequent than previously recogni zed.