1,3-DINITROPROPANES - INTERMEDIATES TO 1, 3-DIAMINOPROPANES

Authors
MAHBOOBI S GROTHUS G
Citation
S. Mahboobi et G. Grothus, 1,3-DINITROPROPANES - INTERMEDIATES TO 1, 3-DIAMINOPROPANES, Archiv der pharmazie, 327(6), 1994, pp. 349-358
Citations number
26
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
327
Issue
6
Year of publication
1994
Pages
349 - 358
Database
ISI
SICI code
0365-6233(1994)327:6<349:1-IT13>2.0.ZU;2-0
Abstract
Reduction of malodininiles 4 and 10 to the corresponding diamines does not work. - Reduction of dinitro-2-(indol-3-yl)-propanes 13 and 16 an d subsequent reaction with K2PtCl4 afford the corresponding dichloropl atinum(II) complexes 14 and 17. Complexes 17 show weak binding affinit ies to the estrogen receptor and no antitumor activity towards MCF-7- and MDA-MB-2231-cell lines. - Twofold addition of nitromethane to alde hyde 24 is possible.