G. Bettinetti et al., THERMAL-ANALYSIS OF THE DEHYDRATION PROCESS OF CROSS-LINKED POLYVINYLPYRROLIDONE AND ITS MIXTURES WITH NAPROXEN, Drug development and industrial pharmacy, 20(14), 1994, pp. 2215-2225
Ways of finding kinetic parameters useful for pharmaceutical formulato
rs from thermal analytical methods (TGA, DSC) under both isothermal an
d non-isothermal conditions are suggested. We considered as an example
those followed to determine the first-order kinetics of dehydration o
f cross-linked polyvinylpyrrolidone (PVP XL). PVP XL samples differing
in particle size (granulometric fractions in the 250 mu m to 63 mu m
range) and/or equilibrium moisture content (12 to 32 g(H2O)/100 g) sho
w activation energy values in the 43 to 54 kJ mol(-1) (non-isothermal
TGA) and 48 to 61 kJ mol(-1) (non-isothermal DSC) ranges. The weight f
raction of water present may influence the activation energy of the de
hydration process whilst the particle size of PVP XL seems not to affe
ct this parameter. The low interaction energy between PVP XL and water
suggests that the interaction mainly occurs within the porous agglome
rates of the polymer particles, at the intraparticulate surface level
(surface-type interaction). The influence of an admired drug (naproxen
) on the thermodynamic and kinetic parameters of PVP XL dehydration su
ggests that analogous surface phenomena are probably involved in the s
olid-state interaction between the amorphous polymer and the crystalli
ne drug.