VALIDATION OF AN AUTOMATED SAMPLING SYSTEM WITH FRANZ DIFFUSION CELLS

Transdermal penetration studies ''in vitro'' are tedious and time cons uming, and sometimes require complex sampling schedules. If automatic equipment is used, full validation is mandatory. The aim of this study was to validate an automated ''in vitro'' sampling system using modif ied Franz diffusion cells. The reproductibility of sample and replace volumes was assessed. The dilution effect induced by the replaced volu me was also studied and some equations in order to correct this factor were propossed. Ketorolac trometamol has been used as a model drug in this study.