STABILITY PREDICTION OF CEFAZOLIN SODIUM AND CEPHALORIDINE IN SOLID-STATE

The stability of commercially-available solid pharmaceutical preparati ons containing cephaloridine and cefazolin sodium was evaluated with a n accelerated isothermal degradation method at three different tempera tures (37 degrees, 45 degrees and 60 degrees C). A specific and sensit ive differential pulse polarographic method was used for cephalosporin determination. Data obtained from high-temperature studies were proce ssed using Arrhenius relation to predict shelf-life. The greater therm al stability of cephaloridine than cefazolin sodium was found, in cont rast to what can be deduced from official monographs. Differential sca nning calorimetry and X-ray diffraction were used to characterize the solid state of cephalosporin antibiotics.