EXPOSURE OF INTESTINAL SEGMENTS TO HEMIACIDRIN - ANALYSIS OF METABOLIC AND HISTOLOGICAL EFFECTS USING A RAT MODEL

Using a previously reported rat model, we examined the effects of inte stinal perfusion with hemiacidrin on calcium and magnesium homeostasis , and inspected the intestinal segments for histological alterations f ollowing exposure to the solution. Intestinal irrigation with hemiacid rin resulted in a significant increase in serum magnesium. Urinary exc retion rates of calcium increased 8-fold and magnesium excretion rates increased 5-fold over control values. Hemiacidrin appeared to have de trimental effects on the integrity of the intestinal mucosa, and irrig ation should be done with caution in patients whose urinary tract has been reconstructed with intestinal segments.