3 DRUGS INHIBIT PHOSPHOLIPASE-A(2)-INDUCED HIGH PERMEABILITY OF ENDOTHELIAL MONOLAYERS

Authors
CHEN SF LI SH DING FY
Citation
Sf. Chen et al., 3 DRUGS INHIBIT PHOSPHOLIPASE-A(2)-INDUCED HIGH PERMEABILITY OF ENDOTHELIAL MONOLAYERS, Zhongguo yaoli xuebao, 15(4), 1994, pp. 299-302
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Zhongguo yaoli xuebao → ACNP
ISSN journal
02539756
Volume
15
Issue
4
Year of publication
1994
Pages
299 - 302
Database
ISI
SICI code
0253-9756(1994)15:4<299:3DIPHP>2.0.ZU;2-Y
Abstract
The permeability of aortic endothelial monolayers to fluid and albumin increased 13.5 and 16.1 times respectively after pretreatment with ph ospholipase A(2) (PLA(2), 100 U . ml(-1)) for 30 min. 1-(p-Chlorobenzo yl)-5-methylindole-3-acetic acid (1.16 mmol . l(-1)), SRI 63-441 (30 n mol . L(-1)), and 1,25-dihydroxycholecalciferol (0.1 mu mol . L(-1)) d ecreased PLA(2)-induced high permeability. PLA(2) did not damage the e ndothelial cells significantly. Our results indicate that the action o f PLA(2) to increase the permeability of endothelial monolayers is mai nly due to PLA(2)-induced lipid mediators-released from endothelial ce lls.