TESTING OF LIPOXYGENASE INHIBITORS, CYCLOOXYGENASE INHIBITORS, DRUGS WITH IMMUNOMODULATING PROPERTIES AND SOME REFERENCE ANTIPSORIATIC - DRUGS IN THE MODIFIED MOUSE TAIL TEST, AN ANIMAL-MODEL OF PSORIASIS

Topical administration of lipoxygenase and cyclooxygenase inhibitors, antipsoriatic drugs and some immunomodulating drugs on adult mouse tai l scales showed variable induction of of orthokeratosis. Dithranol and retinoic acid showed ED(50) concentrations of 0.5% and 0.23%, respect ively. The lipoxygenase inhibitors catechol and octyl gallate showed E D(50) of 2.5 and 13.4%. 10% lonapalene showed 20% activity, curcumin, linoleic acid, primrose oil and AA 673 10-15% activity, methyl and eth yl gallate 5% activity, nordihydroguaiaretic acid, diethylcarbamazine, ebselen, esculetin, quercetin, AA861, gallic acid, dodecyl gallate an d 15-hydroxyeicosatetraenoic acid no activity. The cyclooxygenase inhi bitors indomethacin, acetylsalicylic acid and bufexamac were inactive, benoxaprofen showed 14% activity. The immunomodulating drugs fluorour acil and triamcinolone showed >10% activity, cyclosporin A and thalido mide no activity. Fumaric acid showed 5% activity. The results show th at this model could be proposed for screening antipsoriatic drugs.