EVIDENCE FOR GENETIC CONTAMINATION OF INBRED BUFFALO RATS (RT-1(B)) OBTAINED FROM A COMMERCIAL VENDOR

Authors
JONES RE WEINBERG A BOURDETTE D
Citation
Re. Jones et al., EVIDENCE FOR GENETIC CONTAMINATION OF INBRED BUFFALO RATS (RT-1(B)) OBTAINED FROM A COMMERCIAL VENDOR, Journal of neuroimmunology, 52(2), 1994, pp. 215-218
Citations number
6
Categorie Soggetti
Neurosciences,Immunology
Journal title
Journal of neuroimmunology → ACNP
ISSN journal
01655728
Volume
52
Issue
2
Year of publication
1994
Pages
215 - 218
Database
ISI
SICI code
0165-5728(1994)52:2<215:EFGCOI>2.0.ZU;2-Y
Abstract
Inbred Buffalo rats (RT-lb) have been used in studies of experimental autoimmune encephalomyelitis and autoimmune thyroiditis. Since our stu dies, and those of others, have relied on the genetic purity of inbred Buffalo rats, we chose to test these animals for expression of strain -dependent, allotype-specific variants of CD45 (leukocyte common antig en, LCA) using the monoclonal antibodies RT7.1 and RT7.2. The goal of this study was to confirm the genetic purity and to verify the inbred status of Buffalo rats obtained from a commercial source.