BEHAVIORAL AND BIOCHEMICAL EFFECTS OF A NEW POTENTIAL NOOTROPIC AGENT- Z4105

Z4105 3-methyl-5-isoxazolylcarbonyl)amino)butanoic)acid] has been comp ared to the reference drugs piracetam and oxiracetam, For its cognitiv e enhancing properties, in a series of biochemical and behavioural stu dies. In these studies, Z4105 was shown to be the most active drug in reverting the amnesic effect of both ECS and MAM, which points to its potential as an agent for improving learning and memory function. The effects of Z4105 on impaired memory induced by cerebral ischaemia are less clear and require further investigation. The biochemical data ind icate that Z4105 increases the activity of the brain cholinergic syste m without affecting other neurotransmitter systems.