CLONING OF A CDNA-ENCODING A PUTATIVE NICOTINIC ACETYLCHOLINE-RECEPTOR SUBUNIT OF THE HUMAN FILARIAL PARASITE ONCHOCERCA-VOLVULUS

Authors
AJUH PM EGWANG TG
Citation
Pm. Ajuh et Tg. Egwang, CLONING OF A CDNA-ENCODING A PUTATIVE NICOTINIC ACETYLCHOLINE-RECEPTOR SUBUNIT OF THE HUMAN FILARIAL PARASITE ONCHOCERCA-VOLVULUS, Gene, 144(1), 1994, pp. 127-129
Citations number
13
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
144
Issue
1
Year of publication
1994
Pages
127 - 129
Database
ISI
SICI code
0378-1119(1994)144:1<127:COACAP>2.0.ZU;2-9
Abstract
A partial cDNA clone encoding a putative nicotinic acetylcholine recep tor (ACHR) subunit of the human filarial parasite, Onchocerca volvulus , has been isolated and sequenced. A truncated open reading frame of 1 308 bp capable of encoding 436 amino acids with a calculated M(r) of 5 1209 was identified. The absence of the double cysteine residues neces sary for neurotransmitter binding indicates that the cloned ACHR is a non-alpha subunit.